About Us

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ITSIBIO is a premier manufacturer of turnkey biomedical research kits, offering cutting-edge genomics, proteomics, and mass spectrometry services that are fast, accurate, and cost-effective.

We have partnered with several renowned companies to provide our clients with access to QuantiGene products, custom ELISA kits, DNA/protein arrays, and innovative DNA storage solutions at competitive prices.

Medical Research

Who We Serve

ITSIBIO was created especially to offer integrated genomics, proteomics, and biomarker discovery/validation services to independent researchers and research teams who need to produce high-quality results quickly and at a reasonable price.

Our team of senior scientists has extensive experience and manages every project with discretion and professionalism. They frequently communicate with the customer using cutting-edge web-based tools. The staff’s commitment and adaptability are unmatched, and ITSIBIO solution-focused strategy ensures that all stakeholders receive the highest return on investment.

We also collaborate with researchers from academic medical centers, study institutes, biotechnology firms, pharmaceutical firms, and universities to initiate exposure to various technological advancements. Contact us for more information.

Cancer Cells Analysis in Laboratory
BioScience Research at ITSI Bio

Our Mission

ITSIBIO aims to offer cutting-edge bioanalytical solutions to the global scientific community. To support its partners’ success, ITSIBIO pledges to deliver the highest quality services at competitive prices with quick turnaround times.

Corporate Values

ITSIBIO adheres to the highest standards of education, quality assurance, quality control, and safety, maintaining strict compliance with Good Laboratory Practices (GLP). Our work culture promotes innovation, dedication, hard work, and diligence among our staff, and we consistently reward our employees for their contributions.

Medical Research
Laboratory Research

Our Projects

We have collaborated with researchers from various sectors, including universities, academic medical centers, research institutes, biotechnology firms, and pharmaceutical companies. Check out the list of projects below.

Learn More

  • Microbio Forensic for BioDefence – Indiana University of Pennsylvania, Indiana, PA, USA.
  • Application of proteomics to elucidate the effects of caloric restriction and radiation on breast cancer in mice – Thomas Jefferson University, Philadelphia, PA, USA.
  • Proteomic identification of Target for Breast Cancer Therapy – Windber Research Institute, Windber, PA USA.
  • Proteomics studies on the mechanisms of blast-induced traumatic brain injury using the in-vitro model system – Walter Reed Army Institute of Research 503 Robert Grant Ave Silver Spring, MD 20910
  • Aging quantification of mhc-ii alpha e peptide in 3 and 22 months mouse-project I – Albert Einstein College of Medicine, NY, USA.
  • LC-MS/MS Analysis of Serum Depleted Noninfected (EC) and VL-Infected (VL) – Infectious Disease Research Institute, Seattle, WA, USA.
  • Aging quantification of mhc-ii alpha e peptide in 3 and 22 months mouse-project II – Albert Einstein College of Medicine, Bronx, NY, USA.
  • Studies on the mechanisms of blast-induced traumatic brain injury using an in-vitro model systems – University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Proteomics of SMOC-Associated proteins – U.S. Food and Drug Administration, CBE Bethesda, MD, USA.
  • PTM analysis on tp2 – CHROMATIN BIOLOGY LAB, Molecular Biology and Genetic Unit, JNCASR, Bangalore, India.
  • Proteomics Study of Lung Cells – University of Texas at Dallas, Dallas, TX, USA.
  • Studies on the mechanisms of blast-induced traumatic brain injury using the in-vitro model system – Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • LC-MS/MS Analysis of Serum Depleted Noninfected (EC) and VL-Infected (VL) – Infectious Disease Research Institute, Seattle, WA, USA.
  • Aging quantification of mhc-ii alpha e peptide in 3 and 22 months mouse-project – Albert Einstein College of Medicine, Bronx, NY, USA.
  • LC-MS/MS Analysis of Serum Depleted Noninfected (EC) and VL-Infected (VL) – Infectious Disease Research Institute, Seattle, WA, USA.
  • Identification of stat2 dependent inflammatory mediators – NCI-Frederick, Frederick, MD, USA.
  • Studies on the mechanisms of blast-induced traumatic brain injury using an in-vitro model system – University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • PTM ANALYSIS On HILS1 – CHROMATIN BIOLOGY LAB, Molecular Biology and Genetic Unit, JNCASR Bangalore, India.
  • Protein identification from tryptic digestion – Albert Einstein College of Medicine, Bronx, NY, USA.
  • LC-MS/MS Analysis of Purified LdPDI Protein – Infectious Disease Research Institute, Seattle, WA, USA.
  • Identification of Trypanosoma brucei Sumoylated proteins – Avenida General Paz 5445 INTI-Edificio 19, Bueno Aires, Argentina.

Publications

Browse through our comprehensive list of scientific publications and research papers our team of experts produced.

41. Identification of Protein Markers in Patients Infected with Plasmodium knowlesi, Plasmodium falciparum and Plasmodium vivax.

Alan Kang-Wai Mu 1Ping Chong Bee 2Yee Ling Lau 3Yeng Chen 4 Int J Mol Sci. 2014 Nov 3;15(11):19952-61. doi: 10.3390/ijms151119952.

40. AMP-activated protein kinase mediates insulin-like and lipo-mobilising effects of β-glucan-rich polysaccharides isolated from Pleurotus sajor-caju (Fr.), Singer mushroom, in 3T3-L1 cells.

G Kanagasabapathy 1K H ChuaS N A MalekS VikineswaryU R Kuppusamy. Journal of Food Chemistry. 2014 Feb 15;145:198-204. doi: 10.1016

39. A colorimetric method for monitoring tryptic digestion prior to shotgun proteomics.

Somiari RI, Renganathan K, Russell S, Wolfe S, Mayko F, Somiari SB.Int J Proteomics. 2014;2014:125482. doi: 10.1155/2014/125482.

38. Wortmannin potentiates the combined effect of etoposide and cisplatin in human glioma cells.

37. DNA aptamers against exon v10 of CD44 inhibit breast cancer cell migration.

36. A Novel Type of Hemocytes Localizing Melanization with High-Spreading Behavior in Mythimna Separata.

 Yoshiaki Kato, Tatsuhiro Yoshida, Ken Miura, Toshiharu Tanaka, Yutaka Nakamatsu, Masanori OchiaiArchives of Insect Biochemistry and Physiology 2014 Jul DOI: 10.1002/arch.21173

35. Identification of STAT2 serine 287 as a novel regulatory phosphorylation site in type I interferon-induced cellular responses.

34. COPD is associated with production of autoantibodies to a broad spectrum of self-antigens, correlative with disease phenotype.

T. A. Packard, Q.Z. Li, G.P. Cosgrove, R.P. Bowler, J.C. Cambier Immunol Res (2013) 55:48–57, September 2012. Springer Science+Business Media

33. Acute mitochondrial dysfunction after blast exposure: potential role of mitochondrial glutamate oxaloacetate transaminase.

32. Modulation of hearing related proteins in the brain and inner ear following repeated blast exposures.

31. Exploration of the binding proteins of perfluorooctane sulfonate by a T7 phage display screen.

30. Beta-Catenin Phosphorylated at Threonine 120 Antagonizes Generation of Active Beta-Catenin by Spatial Localization in trans-Golgi Network.

29. How the Surface Nanostructure of Polyethylene Affects Protein Assembly and Orientation.

James D. Bortner, Arunangshu Das, Todd M. Umstead, Williard M. Freeman, Richard Somiari, Cesar Aliaga, David S. Phelps, . ACS Nano. 03/2011; 5(4).

28. Method for releasing reducing Glycan by Ammonium Salt.

 Nishimura, Shin-ichiro, Miura, YoshiakiFree Patents online. 2011 November 10, patent:20110275108

27. Senescence Marker Protein 30 (SMP30) Expression in Eukaryotic Cells: Existence of Multiple Species and Membrane Localization.

26. The effect of selenium enrichment on baker’s yeast proteome.

25. Repeated Blast Exposures Lead to Changes in Hearing Related Gene Expression in Mice Brain.

24. Effect of Immunohistochemistry on Molecular Analysis of Tissue Samples.

23. Differential profile analysis of urinary cytokines in patients with overactive bladder.

G.Ghoniem., N. Faruqui., M. ElmissiryInt. Urogynecol J Springer. 2011 April13; 22:953-961

22. Polyphenols Activate Nrf2 in Astrocytes Via H2O2, Semi-Quinones and Quinones.

H. Erlanka, A. Elmanna, R. Kohenb, J. Kanner Free Radical Biology and Medicine-Elsevier Inc. 2011 September 28;10.1016

21. Sample Preparation for 2D Electrophoresis and CE-Based Proteomics .

 J. M. Nagy, A. Lipka, F. Pereira, N. Marlin, S. Hassard Springer Science+Buisness Media (google book) 2011.

20. STR Analysis of Human DNA Samples After Dry-State Ambient Temperature Storage in Geneplates.

19. Selenium-Responsive Proteins in the Sera of Selenium-Enriched Yeast-Supplemented Healthy American and Caucasian Men.

R. Sinha., I. Sinha., N. Facompreruqui., M. ElmissiryJournal of Biomedical Science. 2009 September;35(3):559-67.

18. Down-regulation of 14-3-3 isoforms and annexin A5 proteins in lung adenocarcinoma induced by the tobacco-specific nitrosamine NNK in the A/J mouse revealed by proteomic analysis.

Bortner JD Jr, Das A, Umstead TM, Freeman WM, Somiari R, Aliaga C, Phelps DS, El-Bayoumy K. J Proteome Res. 2009 Aug;8(8):4050-61. doi: 10.1021/pr900406g

17. Characterization of membranous and cytoplasmic EGFR expression in human normal renal cortex and renal cell carcinoma.

16. Proteomics of rat prostate lobes treated with 2-N-Hydroxylamino-1-methyl-6-phenylimidazo [4,5-b] pyridine, 5alpha-dihydrotestosterone, individually and in combination.

 Boyiri, T., Somiari, RI., Russell, S., EL-Bayoumy, KInt. J Oncol. 2009 Sep;35(3):559-67

15. Circulating MMP2 and MMP9 in breast cancer – potential role in classification of patients into low risk, benign disease and breast cancer categories.

14. Plasma activity of matrix metalloproteinase 2 and 9 in breast disease.

13. Proteomics of breast carcinoma.

Somiari RI, Somiari S, Russell S, Shriver CDJ Chromatogr B Analyt Technol Biomed Life Sci. 2005 Feb 5;815(1-2):215-25.

12. Difference gel Electrophoresis in a High throughput Research Environment.

Somiari RI. Russell S, Somiari SB, Sullivan AG, Ellsworth, DL, Brzeski, H, Shriver, CD In Walker J. (Editor) The Proteomics Protocols Handbook. Humana Press Inc., NJ, USA. 2005;pp. 223 – 237.

11. Laser assisted microdissection in proteomic analyses.

Ellsworth DL, Russell S, Deyarmin B, Sullivan A, Brzeski H, Somiari RI, Shriver CD . In Walker J. (Editor) The Proteomics Protocols Handbook. Humana Press Inc., NJ, USA. 2005;pp. 59-66.

10. Large-format two dimensional polyacrylamide gel electrophoresis.

 Brzeski, H., Sullivan, A., Somiari, R., & Shriver, C. In Walker J. (Editor) The Proteomics Protocols Handbook. Humana Press Inc., NJ, USA. 2005;pp. 119-132.

9. Serum or Plasma Sample Preparation for Two-Dimensional Gel Electrophoresis.

Sullivan, A., Brzeski, H., Somiari, R., & Shriver, C. In Walker J. (Editor) The Proteomics Protocols Handbook. Humana Press Inc., NJ, USA. 2005; pp. 49-54.

8. Anti-Sm and anti-RNP antibodies.

P. MIGLIORINI, C. BALDINI, V. ROCCHI, & S. BOMBARDIERI Autoimmunity, February 2005; 38(1): 47–54

7. Global search for chromosomal abnormalities in infiltrating ductal carcinoma of the breast using array-comparative genomic hybridization.

6. Albumin depletion method for improved plasma glycoprotein analysis by two-dimensional difference gel electrophoresis.

5. High-throughput proteomic analysis of human infiltrating ductal carcinoma of the breast.

4. High-throughput loss of heterozygosity mapping in 26 commonly deleted regions in breast cancer.

Ellsworth RE, Ellsworth DL, Lubert SM, Hooke J, Somiari RI, Shriver CD. Cancer Epidemiol Biomarkers Prev. 2003 Sep;12(9):915-9

3. Laser capture microdissection of paraffin-embedded tissues.

2. Heat shock cognate-70 gene expression decreases during normal aging of the primate retina.

1. A high-density differential screening strategy for identification of fovea genes with altered expression in the retina during aging.

R. I. Somiari, P. Wong, S. L. Bernstein. Biotechnology Techniques 1999 13 (9): 577-581